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KMID : 0545119960060040265
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Journal of Microbiology and Biotechnology
1996 Volume.6 No. 4 p.265 ~ p.269
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Isolation, Physico-chemical Properties and Biological Activity of Aurodox Group Antibiotics
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KIM, SI-KWAN
YEO, WOON-HYUNG/KIM, SANG-SEOCK
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Abstract
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An isolate of Streptomyces rochei synonym was found to produce antibiotics with narrow antimicrobial spectrum against Streptococcus and Xanthomonas sp. Among the antibiotic complex produced by the strain, the main active compoun was isolated, and its physico-chemical properties and biological activities were investigated. Molecular weight if the compound was determined to be [M+H]^+ 797 (FAB-MS). UV, ^1H and ^13C NMR, and IR spectra suggested that the compound is a lirromycin-like aurodox group antibiotic. Houever, the antimicrobial spectrum of the main compound was slightly different from that of kirromycin. In addition, it was newly found that lirromycin showed a selective antimicrobial activity against Streptococcus pyogenes and phytopathogenic Xanthomonas sp.
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